This can cause abdominal pain, cramps, diarrhea, and fever. In some cases, high -volume, diarrhea is so frequent that the person develops. In the worst cases, long-term antibiotic use can even lead to C. diff, a severe infection that causes colitis, or inflammation in your colon. C. difficile is a toxin-producing bacterium that can cause a more serious antibiotic -associated diarrhea. In addition to causing loose stools and. Other than the brown discoloration, the boy's physical condition was normal and the discoloration disappeared within 1 month. Doctors mix and blend it with a salt solution to make a slurry. Do not take any medicine to treat diarrhea without first checking with your doctor. For safety, tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements. Examples of drugs that can cause this type of interaction include:. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. This site complies with the HONcode standard for trustworthy health information: verify here. Check with your doctor immediately if any of the following side effects occur while taking doxycycline:. This raises your risk of side effects. All rights reserved. If you are being sick, drink plenty of fluids, such as water or squash, to avoid dehydration. Drugs and Supplements Doxycycline Oral Route. This site complies with the HONcode standard for trustworthy health information: verify here. Mayo Clinic Marketplace Check out these best-sellers and special offers on books and newsletters voxycycline Mayo Clinic. Products and services. Always discuss possible side effects with a healthcare provider coes knows your medical history. American College of Gastroenterology.